This is a super simple hug example using Zappa. The only real trick here was knowing to set the app setting in the zappa_settings.json file. Hug provides a magic method for the wsgi compatible server that should be given to Zappa.
"app_function": "app.__hug_wsgi__"
Make sure you modify your zappa s3_bucket setting prior to deployment.
python -m venv env
source env/bin/activate
pip install -r requirements.txt
zappa deploy