diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index fa235cf816aab..aa035b3ba1c78 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -42,7 +42,7 @@ jobs:
         python-version: ${{ matrix.python }}
         architecture: ${{ matrix.arch }}
     - name: install tox
-      run: pip install --upgrade 'setuptools<50' 'virtualenv<20' tox==3.9.0
+      run: pip install --upgrade 'setuptools!=50' 'virtualenv<20' tox==3.9.0
     - name: setup tox environment
       run: tox -e ${{ matrix.toxenv }} --notest
     - name: test
diff --git a/test-requirements.txt b/test-requirements.txt
index 1d348cbb8d125..1f5e9e1a5c83d 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -12,5 +12,5 @@ pytest-cov>=2.10.0,<3.0.0
 typing>=3.5.2; python_version < '3.5'
 py>=1.5.2
 virtualenv<20
-setuptools<50
+setuptools!=50
 importlib-metadata==0.20